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tetrahydrofolate 10-formyltetrahydrofolate NAD+ 5-methyltetrahydrofolate 5,10-methylenetetrahydrofolate NADH ATP 5,10-methenyltetrahydrofolate ADP P NADPH NADP+ formate 3.5.4.9 | methenyltetrahydrofolate cyclohydrolase (cMTHCH) 1.5.1.20 | methylenetetrahydrofolate reductase [NAD(P)H] (cMTFHR) 1.5.1.5 | methylenetetrahydrofolate dehydrogenase (NADP+) (cMTHD) 6.3.4.3 | formate-tetrahydrofolate ligase (cFTHFS)