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L-homocysteine PP ATP CH3 L-methionine tetrahydrofolate 5-methyltetrahydrofolate S-adenosyl-L-homocysteine S-adenosyl-L-methionine P adenosine 2.1.1.- | SAM dependent methyltranferase (simpl.) 3.3.1.1 | adenosylhomocysteinase 2.5.1.6 | methionine adenosyltransferase 2.1.1.13 | methionine synthase (cMS)